兼任教師

顏怡君

職稱：兼任助理教授
德國慕尼黑大學生物學博士
：yichunyen@gmail.com
開設課程：認識心靈：精神醫學之初探

學經歷

  • 德國慕尼黑大學生物學博士
  • 國立台灣大學心理學所碩士

  • 國立台灣大學心理學系學士

歷任職稱

  • 學術經歷：
    新加坡國立大學生理學系博士後研究員
    杜克-新加坡國立大學醫學院神經科學與行為疾患學程博士後研究員
    德國馬克斯普朗克精神醫學研究所博士後研究員
  • 服務經歷：
    東海大學生命科學系助理教授
  • 榮譽：
    2017年榮獲唐獎基金會頒發的「格羅．布倫特蘭獎」
    2010年獲德國馬克斯普朗克機構精神醫學所年度最佳壁報展獎
    95年度教育部公費留學生

專長領域

  • 神經科學
  • 生物心理學
  • 動物行為學
  • 精神疾病研究

論文著作

  • Peng AYT, Agrawal I, Ho WY, Yen YC, Pinter AJ, Liu J, Phua QXC, Koh KB, Chang JC, Sanford E, Man JHK, Wong P, Gutmann DH, Tucker-Kellogg G, Ling SC, 2020. Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction. Proc Natl Acad Sci U S A. 117(46):29101-29112.
  • Wong PY, Ho WY, Yen YC, Sanford E, Ling SC, 2020. The vulnerability of motor and frontal cortex-dependent behaviors in mice expressing ALS-linked mutation in TDP-43. Neurobiol Aging 92:43-60.
  • Ho WY, Chang JC, Tyan SH, Yen YC, Lim K, Tan BSY, Ong J, Tucker-Kellogg G, Wong P, Koo E, Ling SC, 2019. FUS-mediated dysregulation of Sema5a, an autism-related gene, in FUS mice with hippocampus-dependent cognitive deficits. Hum Mol Genet 28(22):3777-3791.
  • Yu W*, Yen YC*, Lee YH, Tan S, Xiao Y, Lokman H, Ting AKT, Ganegala H, Kwon T, Ho WK, Je HS, 2019. Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice. Mol Brain 12(1):29. *Authors contributed equally
  • Husain N*, Yuan Q*, Yen YC, Pletnikova O, Dong QY, Bichler Z, Worley P, Je HS, 2017. TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation. Aging Cell 16(2):281-292. *Authors contributed equally
  • Sun AX, Yuan Q, Tan S, Xiao Y, Wang D, Khoo AT, Sani L, Tran HD, Kim P, Chiew YS, Lee KJ, Yen YC, Ng HH, Lim B, Je HS, 2016. Direct Induction and Functional Maturation of Forebrain GABAergic Neurons from Human Pluripotent Stem Cells. Cell Rep.16(7):1942-53.
  • Montagner A, Korecka A, Polizzi A, Lippi Y, Blum Y, Canlet C, Tremblay-Franco M, Gautier-Stein A, Burcelin R, Yen YC, Je HS, Al-Asmakh M, Mithieux G, Arulampalam V, Lagarrigue S, Guillou H, Pettersson S, Wahli W, 2016. Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals. Sci Rep 6:20127.
  • Yen YC, Gassen NC, Zellner A, Rein T, Landgraf R, Wotjak CT, Anderzhanova E, 2015. Glycogen synthase kinase-3β inhibition in the medial prefrontal cortex mediates paradoxical amphetamine action in a mouse model of ADHD. Front Behav Neurosci 9:67.
  • Dine J, Ionescu IA, Avrabos C, Yen YC, Holsboer F, Landgraf R, Schmidt U, Eder M, 2015. Intranasally Applied Neuropeptide S Shifts a High-Anxiety Electrophysiological Endophenotype in the Ventral Hippocampus towards a “Normal”-Anxiety One. PLoS ONE 10(4):e0120272
  • Slattery DA*, Naik R*, Grund T, Yen YC, Sartori SB, Fuechsl A, Finger BC, Elfving B, Nordemann U, Guerrini R, Calo G, Mathé AA, Wegener G, Singewald N, Czibere L, Landgraf R, Neumann ID, 2015. Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide s receptor activity. J Neurosci 35(11):4599- 613. *Authors contributed equally
  • Yen YC, Anderzhanova E, Bunck M, Schuller J, Landgraf R, Wotjak CT, 2013. Co-segregation of hyperactivity, active stress coping and cognitive dysfunctions in mice selectively bred for low levels of anxiety. Front Behav Neurosci 7:103.
  • Dine J, Ionescu IA, S Jens, Yen YC, Holsboer F, Landgraf R, Schmidt U, Eder M, 2013. Identification of a role for the ventral hippocampus in neuropeptide S-elicited anxiolysis PLoS ONE 8(3):e60219.
  • Kleinknecht KR, Bedenk BT, Kaltwasser SF, Grünecker B, Yen YC, Czisch M, Wotjak CT, 2012. Hippocampus-dependent place learning enables spatial flexibility in C57BL6/N mice. Front Behav Neurosci 6:87.
  • Gonik M, Frank E, Keβler MS, Czamara D, Touma C, Bunck M, Yen YC, Pütz B, Holsboer F,Bettecken T, Landgraf R, Müller-Myhsok B, Czibere L, 2012. Endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model of extremes in trait anxiety. BMC Genomics 13:579.
  • Yen YC, Mauch CP, Dahlhoff M, Micale V, Bunck M, Sartori SB, Singewald N, Landgraf R, Wotjak CT, 2012. Increased levels of conditioned fear and avoidance behavior coincide with elevated phosphorylation of the protein kinase B (AKT) within the amygdala in a mouse model of extremes in trait anxiety. Neurobiol Learn Mem 98(1):56-65.
  • Ionescu IA, Dine J*, Yen YC*, BD, Herrmann L, Holsboer F, Eder M, Landgraf R, Schmidt U, 2012. Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS-receptor expressing neurons. Neuropsychopharmacology 37(6):1323-37. *Authors contributed equally
  • Deussing JM, Breu J, Kühne C, Kallnik M, Bunck M, Glasl L, Yen YC, Schmidt MV, Zurmühlen R, Vogl AM, Gailus-Durner V, Fuchs H, Hölter SM, Wotjak CT, Landgraf R, de Angelis MH, Holsboer F, Wurst W, 2010. Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2. J Neurosci 30(27):9103-16.

開設課程

  • 認識心靈：精神醫學之初探